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A novel role of a lysosomal acid lipase in the regulation of longevity
Author(s) -
Wang Meng
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.471.2
Subject(s) - longevity , lipid metabolism , biology , adipose tissue , metabolism , microbiology and biotechnology , biochemistry , genetics
Lipid metabolism plays a key role in human health and longevity. Dysregulation of lipid metabolism has been implicated in many age‐related diseases. As a major site of lipid metabolism, adipose tissue exerts crucial endocrine effects on aging. However, it remains poorly understood how lipid metabolism is coupled to lifespan control. We found a lysosomal acid lipase that promotes lifespan and healthspan in C. elegans. The underlying molecular mechanisms will be discussed in the talk.