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Omega‐3 Fatty Acids Mitigate Inflammation in Felines with Chronic Kidney Disease
Author(s) -
Harris Mary A,
Lunn Katharine,
Quimby Jessica,
Kim Susan,
Mulligan Christopher
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.43.1
Subject(s) - medicine , creatinine , kidney disease , hematocrit , endocrinology , eicosapentaenoic acid , docosahexaenoic acid , albumin , serum amyloid a , serum albumin , chemistry , hemoglobin , inflammation , fatty acid , polyunsaturated fatty acid , biochemistry
The objective of this study was to examine the relationship of fish oil omega‐3 (n‐3) fatty acids (FA) on inflammatory markers and clinical indices of malnutrition:inflammation syndrome in a feline model of chronic kidney disease. 63 client owned cats (mean age 14.04 ± 3.86 y), with stage 2 and 3 chronic kidney disease (CKD) were studied. Dietary intake of n‐3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were obtained by diet record. Erythrocyte (RBC) membrane n‐3 DHA and EPA were measured by gas chromatography. Markers of inflammation, serum amyloid A (SAA) and alpha‐1 acid glycoprotein (AGP) were measured by feline specific immunoassay and correlated with clinical variables: serum albumin, body condition score (BCS), hemoglobin (Hgb), hematocrit (Hct) and urine protein:creatinine (P:C). Intakes of DHA and EPA were 42.77 ± 74.34 and 36.02± 69.74 mg/day (mean ± SD) respectively. DHA intake was correlated with BCS (r=.299, p=.05) controlled for age, gender and indicators of CKD (BUN, calcium, Hct, potassium and bicarbonate). Mean AGP was 446.98 ± 220.48 ug/ml (range 140 – 1460) and SAA was 11.75 ±25.78 ug/ml (range 0.1 – 151). AGP was inversely correlated with serum albumin (r=−.321, p=.01). The P:C ratio was positively and highly correlated with SAA (r=.338, p=.008) and approaching significance with AGP (r=.237, p=.06). Hgb and Hct levels were negatively and highly correlated with AGP (p=.000) and SAA (p=.04). The results indicate that adequate DHA status may decrease inflammation in CKD and that higher DHA intakes may protect against malnutrition:inflammation syndrome as indicated by BCS and serum albumin in felines with stage 2 and 3 CKD. This research was supported by the USDA, AES Project #COL00631.