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Vitamin D supplementation and insulin sensitivity in early pubertal children: results from the randomized controlled GAPI trial
Author(s) -
Ferira Ashley Jordan,
Laing Emma,
Hausman Dorothy,
Hall Daniel,
Weaver Connie,
McCabe George,
Martin Berdine,
Peacock Munro,
Warden Stuart,
Hill Kathleen,
Lewis Richard
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.41.2
Subject(s) - quantitative insulin sensitivity check index , medicine , insulin resistance , insulin , glycemic , endocrinology , placebo , vitamin d and neurology , randomized controlled trial , insulin sensitivity , anthropometry , alternative medicine , pathology
The dose‐response effect of vitamin D supplementation on insulin sensitivity was examined in healthy early pubertal children (aged 9–13 y), in the Georgia, Purdue, and Indiana University School of Medicine (GAPI) trial. 320 black and white males and females participated in this 12‐week triple‐masked, placebo‐controlled trial. Subjects were randomized to receive placebo or vitamin D 3 (400, 1000, 2000, or 4000 IU/d). Anthropometry, pubertal maturation, body composition, dietary intake, and fasting biochemical indices (glucose and insulin) were assessed. Main time effects were significant (all p<0.004): glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA‐IR) increased, while quantitative insulin sensitivity check index (QUICKI) decreased. The effects of vitamin D supplementation over time were non‐significant for glucose (p=.780), insulin (p=.918), HOMA‐IR (p=.883), and QUICKI (p=.905). We report findings from the first pediatric vitamin D trial to examine insulin sensitivity. Our subjects’ pubertal, normo‐glycemic, and vitamin D sufficient status may explain our null findings. Future research should examine high‐risk pediatric populations, particularly during post‐puberty. Supported by NICHD RO1HD057126 and Allen Foundation grant 2.008.319. Grant Funding Source: NICHD