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Preload of dietary fiber added to oil emulsion efficiently reduces energy intake by systemic PYY and vagal CCK signaling in mice
Author(s) -
RASOAMANANA Rojo,
CHAUMONTET Catherine,
TOME Daniel,
FROMENTIN Gilles,
DARCEL Nicolas
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.40.2
Subject(s) - peptide yy , endocrinology , medicine , cholecystokinin , preload , chemistry , appetite , receptor , biology , neuropeptide , neuropeptide y receptor , hemodynamics
Most of food currently commercialized have large amounts of lipid and have been contributing to the increasing prevalence of obesity. In front of this, adding dietary fiber (DF) to these foods may be an interesting option to fight overfeeding. We tested the hypothesis that mixing DF to oil emulsion (OE) may increase its satiating properties. We developed therefore a DF‐OE preload (guar gum and fructo‐oligosaccharide fibers mixed with 20% OE of rapeseed oil in water, 14% weight per volume of total DF, 1.2 kcal). Compared to OE alone, we found that DF‐OE preload reduced the daily energy intake by 14% in mice fed with standard diet. Exploring underlying mechanisms exhibited that DF‐OE (i) elicited increased Peptide YY (PYY) release at 30min and 3h after treatment and (ii) up‐regulated both hypothalamic melanocortin type 4 receptor (MC4R) transcripts 4‐fold and pro‐opiomelanocortin (POMC) protein 2‐fold (90min and 6h after respectively). Peripheral blockade of cholecystokinin (CCK) ‐1 receptor abolished its effects on food intake while glucagon‐like peptide‐1 receptor blockade had no influence. Taken together, these data show that adding fibers to oil emulsion improves its satiating properties by stimulating anorectic gut‐brain signaling which involve systemic PYY, vagal CCK and hypothalamic POMC/MC4R signaling.