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Serum 25‐hydroxyvitamin D and breast cancer in the military: A nested case‐control study
Author(s) -
Mohr Sharif Burgette,
Gorham Edward D,
Alcaraz John E,
Kane C I,
Macera Caroline A.,
Parsons J Kelley,
Wingard Deborah L,
Horst R,
Garland C F
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.388.3
Subject(s) - nested case control study , medicine , breast cancer , odds ratio , cohort , confidence interval , cancer , case control study , oncology , cohort study , gynecology
The objective of this study was to test whether a relationship exists between prediagnostic serum levels of 25‐hydroxyvitamin D (25(OH)D) and risk of breast cancer in a U.S. military cohort. 600 incident cases of female breast cancer were matched to 600 controls in a nested case‐control study. Conditional logistic regression was used to test the relationship of 25(OH)D to breast cancer risk, controlling for race and age. There was an inverse association between serum 25(OH)D and odds of breast cancer that did not reach statistical significance overall. However, in pairs of white women (N = 122 pairs) whose blood was drawn < 90 d before diagnosis, those in the highest quintile of serum 25(OH)D had 70% lower estimated risk of breast cancer (odds ratio 0.30, 95% confidence interval 0.12–0.74, p < 0.01) compared to those in the lowest. The quintile cut points were < 15, 15–21.7, 27.4–35.1, and > 35.1 ng/ml. In this cohort, the timing of the inverse association of serum 25(OH)D with risk of breast cancer suggests that the effect of serum 25(OH)D on risk of breast cancer is strongest during a critical interval preceding diagnosis, although reverse causation should be ruled out. A model based on anti‐angiogenesis is described. Further research, including cohort studies of serum 25(OH)D status with breast cancer risk and timing, should be performed to confirm this association.