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Alcohol and breast cancer risk in five ethnic groups: the Multiethnic Cohort
Author(s) -
Park Song-Yi,
Kolonel Laurence N.,
Henderson Brian E.,
Wilkens Lynne R.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.388.2
Subject(s) - medicine , hazard ratio , breast cancer , prospective cohort study , confidence interval , proportional hazards model , confounding , cohort study , demography , population , cohort , lower risk , gynecology , cancer , oncology , environmental health , sociology
To assess the relationship of alcohol consumption with postmenopausal breast cancer risk in a multiethnic population, we prospectively examined the association in 85,089 women enrolled in the Multiethnic Cohort in Hawaii and California. During an average follow‐up of 12.4 years, we identified 3,885 incident invasive cases. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazard models, controlling for potential confounders. Higher alcohol consumption was associated with increased risk of breast cancer: compared to nondrinkers, HRs were 1.23 (95% CI: 1.06, 1.42), 1.21 (95% CI: 1.01, 1.45), 1.12 (95% CI: 0.95, 1.31), and 1.53 (95% CI: 1.32, 1.77) for 5‐<10, 10‐<15, 15‐<30, and ≥30 g/day of alcohol, respectively. The positive association was seen in African American, Japanese American, Latino, white, but not Native Hawaiian, women, and in those with tumors that were ER+/PR+, ER+/PR‐, and ER‐/PR‐. The findings from this prospective study support the hypothesis that moderate alcohol consumption increases breast cancer risk in four ethnic groups, independent of ER/PR status. This work was supported in part by the National Cancer Institute (grant number R37 CA54281).