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Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence
Author(s) -
Bard Jean-Marie,
Jaffré Isabelle,
Joalland Marie-Pierre,
Classe Jean-Marc,
Campone Mario,
Bobin-Dubigeon Christine
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.388.1
Subject(s) - pon1 , quartile , medicine , breast cancer , proportional hazards model , logistic regression , paraoxonase , confounding , oncology , survival analysis , gastroenterology , cancer , confidence interval , biology , oxidative stress , genotype , biochemistry , gene
Objective To relate paraoxonase (PON1) activity to survival time and short term death in breast cancer recurrence. Design and methods PON1 activity was measured by its rate of hydrolysis of two different substrates, paraoxon (PON) and phenylacetate (ARE) in 50 patients who experienced disease recurrence for breast cancer. Results were compared between patients surviving more than one year after the analysis (n=22) and those who died within one year (n=28). Results In a logistic regression analysis, ARE was significantly and negatively associated with early death (OR = 0.10 [0.02–0.58], p=0.0109). PON did not reach significance (OR = 0.43 [0.17–1.11], p=0.0826). As assessed by the Kaplan‐Meier method, the survival distributions across quartiles of ARE was significantly different (Log rang test, p=0.0393). The Cox proportional hazards model indicated that quartile 1 of ARE was significantly different from quartile 4 (HR= 5.48 [1.48–20.36], p=0.0110. In a multiple logistic regression analysis model, ARE was independently associated with early death (OR = 0.12 [0.02–0.98], p=0.0476), besides interval time between diagnosis and recurrence (OR = 0.54 [0.27–1.07], p=0.0781) and undernutrition (OR = 3.95 [0.81–19.19], p=0.0883). Conclusion Paraoxonase activity may predict survival in patients with breast cancer recurrence.