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Vitamin D Status in Relation to Metabolic Risk Factors in Older Puerto Ricans
Author(s) -
Jamal-Allial Aziza,
Homsi Yamen,
Tucker Katherine L
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.386.7
Subject(s) - vitamin d and neurology , waist , insulin resistance , medicine , body mass index , endocrinology , metabolic syndrome , population , puerto rican , diabetes mellitus , demography , environmental health , sociology , anthropology
Vitamin D deficiency is a global problem. Several reports suggest an association between plasma 25‐hydroxy vitamin D concentration (25(OH)D) and metabolic risk factors. We examined, corss‐sectionally, the relation between serum 25(OH)D concentration and adiposity and glucose metabolism among 1505 Puerto Rican adults, 484 men and 1058 women aged 45–75 years. Among all participants, body mass index (BMI), glycosylated hemoglobin (HbA1c), insulin resistance (HOMA‐IR), waist circumference (WC) and waist‐to‐hip‐ratio (WHR) showed significant inverse association with plasma 25(OH)D ( P <0.05); but diabetes status and insulin concentration did not. After stratification by sex, 25(OH)D was significantly associated with BMI, HbA1c, HOMA‐IR, WC, and insulin concentration ( P <0.05) in women. Among men, only HbA1c and WHR showed constant inverse association with plasma 25(OH)D ( P <0.05). Women with BMI ≥ 35 or BMI 30–35, respectively, had lower serum 25(OH)D concentrations than women with BMI <25 ( P <0.01 and P <0.001 respectively and p ‐trend=0.001). In conclusion, lower serum 25(OH)D concentration was significantly associated with adiposity measurements and metabolic risk factors in this population of older Puerto Rican adults living in the Boston area. Longitudinal studies are needed to clarify causal pathways. This study was supported by the National Institutes of Health grants P01 AG023394 and P50 HL105185. Grant Funding Source : NIH