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ReishiMax improves antioxidant capacity in an oxidative stress model and extends lifespan in a natural aging model
Author(s) -
Yang Jieying,
Wu Zimei,
Yao Yisang,
Zhang Yan,
Zhao Chunsheng,
Dong Yunzi,
Tan Ningzhi,
Zhu Jia-Shi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.373.2
Subject(s) - oxidative stress , zoology , antioxidant , glutathione , medicine , chemistry , endocrinology , andrology , biology , biochemistry , enzyme
We reported that ReishiMax (RM, a Ganoderma lucidum extract) improved immune functions and inhibited cancer malignancy. We further studied its effect on antioxidant and lifespan extension in mice. (1)Antioxidant study: 2‐mo male mice were randomized to receive 60 days of vehicle or RM at a dose of 175, 350 or 700 mg/kg, and given a dose of 11 Gy 60 Co on Day 60 and sacrificed on Day 64. Compared to radiation controls, 60 days of RM increased plasma GSH by 34–42% (p<0.05) and liver CAT by 19–30% (p<0.01) in the 3 dose groups. RM increased liver GSH‐Rd by 9% (p=0.03, 175 and 350 mg/kg), liver GSH‐Px by 10% and plasma thiol groups by 12% (p<0.01, 700m/kg). (2)Lifespan study: Male and female ICR mice (12‐mo) were randomized to receive vehicle or RM at a dose of 175, 350 or 700 mg/kg prior mixed with forage. Calorie intake was adjusted twice a week to match the levels for controls. Compared to controls, the median lifespan was extended with RM by 35–69 days, lifespan of the longest surviving mice by 186–262 days, and the maximal lifespan (average of the longest 10% lifespan) by 124–191days (p<0.05). Kaplan‐Meier Survivor analysis showed significantly extended lifespan and reduced death risks with RM, with the best survivor curve observed in mice at RM 175 mg/kg (p=0.02). In conclusion, RM extends lifespan in natural aging mice and improves antioxidant capacity in oxidative stress mice, supporting in general the anti‐aging activity of RM.