Premium
Memory performance is related to dietary, metabolic, and inflammatory parameters in older adults
Author(s) -
Ballantyne Danielle Lynn,
Shidler Marcelle D.,
Krikorian Robert,
Lee Seung-Yeon
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.367.2
Subject(s) - medicine , california verbal learning test , glycemic , gerontology , national health and nutrition examination survey , micronutrient , insulin , vitamin d and neurology , verbal learning , cognition , endocrinology , demography , population , environmental health , pathology , psychiatry , sociology
To examine the association of cognitive function to dietary intake and serum insulin and inflammatory markers, we collected data from 38 older adults (72.5±4.9 yrs) with mild cognitive impairment. More than half were females (57.9%), 94.7% were White Americans, and 89.4% had some college or above. Cognitive function was assessed using the Verbal Paired Associate Learning Test (V‐PAL) and California Verbal Learning Test (CVLT). Three day food records were entered into the Nutrition Data System for Research and nutrient intake and glycemic index were calculated. Fasting blood samples were obtained to assay serum insulin, C‐reactive protein, TNF‐α, IL‐1 β, and IL‐6. Regression analyses were conducted using SPSS 19. Vitamin D intake (p<0.001), TNF‐α (p<0.001), and glycemic index (p<0.001) explained 48.4% variance of the V‐PAL total learning score. With respect to the CVLT, the total number of intrusion errors was predicted by insulin (p<0.05, r 2 =11.2%) and long‐delay free recall was predicted by age (p<0.05, r 2 =14.2%). These preliminary findings suggest that nutritional and metabolic status may be related to cognitive function in older adults. These associations need to be examined with a larger sample. NIH/National Institute on Aging grant # R01 AG034617 and the US Highbush Council