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Nutrient biomarker patterns and rates of cognitive decline in dementia‐free elders
Author(s) -
Bowman Gene L.,
Quinn Joseph F.,
Kaye Jeffrey A.,
Shan Jackilen
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.367.1
Subject(s) - biomarker , dementia , cognitive decline , medicine , nutrient , gerontology , cognition , vitamin d and neurology , disease , biology , ecology , psychiatry , genetics
Background We previously identified three distinct nutrient biomarker patterns associated with both psychometric and neuroimaging indices in a cross‐sectional analysis. The objective of this study was to examine the relationship between the nutrient biomarker patterns and cognitive decline over 2 years. Methods Thirty biological markers of diet were assayed in plasma drawn from 104 dementia‐free participants of the Oregon Brain Aging Study. Principal component analysis constructed 8 distinct nutrient biomarker patterns. A linear regression model was used to examine the change in the Clinical Dementia Rating ‐ sum of box score over two years explained by the nutrient biomarker patterns. Results Mean age was 87±10, 62% are female, and 10% are carrying the ApoEe4 allele. Two distinct nutrient biomarker patterns were associated with rates of cognitive decline: a vitamin pattern high in vitamins B, C, E and D (p=0.001) and a high trans fat pattern (p<0.001) associated with less and more decline over two years, respectively. These findings were independent of age, gender, education years, ApoEe4 carrier status and vascular risk factors. Conclusion A nutrient biomarker pattern high in specific vitamins and low in trans‐fat may offer a prudent profile for promoting cognitive health in older populations. Funding: NIH/NCCAM AT004777 (GLB), NIH/NIA AG08017 (JAK), NIH/NCRR UL1 RR024140Grant Funding Source : NIH AT004777