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Acute neurocognitive effects of multi‐vitamin/mineral preparations on brain imaging assessed with Steady State Topography and fMRI during periods of mental effort
Author(s) -
Scholey Andrew,
Maggini Silvia,
Camfield David,
Bauer Isabelle,
Neale Chris,
White David,
Savage Karen,
Stough Con
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.365.4
Subject(s) - neurocognitive , crossover study , placebo , multivitamin , functional magnetic resonance imaging , effects of sleep deprivation on cognitive performance , medicine , cognition , brain function , magnetic resonance imaging , vitamin d and neurology , vitamin , neuroscience , psychology , pathology , radiology , alternative medicine
The objective of this study was evaluate the acute effects of multi‐vitamin/mineral preparations, both with and without guaraná, on cognitive function and brain activation. Fifteen healthy young adults took part in a double‐blind, placebo‐controlled crossover study. Cognitive function was assessed 30 min following placebo, a multivitamin/mineral (MV) preparation (Berocca Performance™) and a MV preparation with guaraná (Berocca Boost™) with a > 48 h washout period. Brain bioelectric activity was assessed using Steady State Tomography (SST), a methodology which is sensitive to nutritional interventions. An additional 5 participants underwent functional magnetic resonance imaging (fMRI) during information processing tasks. Berocca Boost™ improved working memory performance which may be attributable to its guaraná content. The two MV treatments resulted in differential patterns of brain activation using both SST and fMRI which were consistent with improved neural efficiency during activation tasks. These data demonstrate that multi‐vitamin/mineral administration can acutely improve neurocognitive functioning by increasing neural efficiency. This research was supported by Bayer AG.