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Mechanisms of transcriptional regulation in the p53 network
Author(s) -
Espinosa Joaquin
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.344.1
Subject(s) - biology , transcription factor , suppressor , small hairpin rna , gene , computational biology , regulation of gene expression , senescence , cell cycle checkpoint , autophagy , gene regulatory network , cell cycle , microbiology and biotechnology , genetics , gene expression , apoptosis , rna
The tumor suppressor p53 is transcription factor that orchestrates diverse responses to cellular stress via regulation of target genes involved in cell cycle arrest, senescence, autophagy and apoptosis. The p53 transcriptional program varies greatly in a cell type‐ and stimulus‐specific manner, but the mechanisms generating this regulatory diversity are poorly defined. We have recently performed several genomics studies that revealed novel mechanisms conferring regulatory diversity to the p53 network. These experiments include shRNA screens for gene‐specific p53 cofactors and identification of novel p53‐regulated RNAs via global run‐on deep sequencing. We will present the results of these experiments and discuss new strategies to manipulate the p53 response for therapeutic purposes.