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The role of the transcription factor BCL11B in the regulation of growth and asymmetric development of the mouse incisor
Author(s) -
Kyrylkova Kateryna,
Kyryachenko Sergiy,
Kioussi Chrissa,
Leid Mark
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.339.2
Subject(s) - ameloblast , transcription factor , microbiology and biotechnology , incisor , organogenesis , biology , regulator , enamel paint , dentistry , medicine , gene , genetics , ecology
Development of the mammalian tooth has been intensively studied as a model system for epithelial‐mesenchymal interactions during organogenesis. Furthermore, the mouse incisor regenerates constantly and thus is an excellent model to analyze regulatory pathways that affect dental stem cells. In addition, enamel on the mouse incisor is deposited asymmetrically, which allows the study of differential patterning of the tooth. The transcription factor BCL11B plays essential roles in the development of immune, central nervous, and cutaneous systems. Bcl11b −/− mice are characterized by poorly developed teeth, however, little is known about the role of BCL11B throughout incisor development. We investigated the Bcl11b −/− incisor morphology, proliferation, and expression of growth and transcription factors that are crucial for incisor development throughout mouse embryogenesis. We show that BCL11B regulates the expression of several signaling molecules and is essential for epithelial proliferation and asymmetric development of the incisor. In addition, BCL11B contributes to the proper differentiation and localization of enamel‐secreting cells, known as ameloblasts. In conclusion, we demonstrated that BCL11B functions as a critical regulator of proper incisor development, and this study may contribute to the generation of the bioengineered teeth. Grant Funding Source : DE021879 from NIDCR to ML