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Role of PINCH in regulating liver size and termination of liver regeneration
Author(s) -
donthamsetty shashi,
Mars Wendy,
Wu Cary,
Michalopoulos George
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.274.8
Subject(s) - liver regeneration , regeneration (biology) , extracellular matrix , hepatectomy , chemistry , microbiology and biotechnology , medicine , endocrinology , biology , surgery , resection
This study investigates the role of PINCH in regulation of liver size and termination of liver regeneration. This protein is a part of the ternary complex known as the IPP (Integrin linked kinase‐ Pinch‐Parvin) complex. We generated PINCH 1 and PINCH 2 double KO mice (referred as PINCH1/2 KO mice). Mice under the above conditions were born normal. However, they develop histologic abnormalities characterized by disorderly hepatic plates, increased proliferation of hepatocytes and biliary cells and increased deposition of extracellular matrix. After a sustained and prolonged proliferation of all epithelial components, proliferation subsides and final liver weight by the end of 30 weeks in livers with PINCH1/2 deficient hepatocytes is 40% larger than the WT mice. These mice when subjected to 70% partial hepatectomy regenerated normally and did not show any termination defect. In conclusion, PINCH is involved in regulating liver size but not terminating liver regeneration.