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Lipoprotein cholesterol distribution and LDL particle size is proatherogenic in Mexican Americans with metabolic syndrome
Author(s) -
Pignotti Giselle Adriana Pereira,
Neupane Srijana,
Farr Kristin J,
Vega-López Sonia
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.252.7
Subject(s) - medicine , waist , endocrinology , metabolic syndrome , cholesterol , ldl cholesterol , lipoprotein , chemistry , distribution (mathematics) , lipoprotein particle , high density lipoprotein , triglyceride , body mass index , obesity , very low density lipoprotein , mathematical analysis , mathematics
To evaluate the association between components of metabolic syndrome (MS) and lipoprotein cholesterol (C) distribution in Mexican‐American adults, the distribution of C in LDL and HDL subfractions and the presence of MS were assessed in 72 healthy participants (25 male, 47 female; age=37±9 y; BMI=28.9±5.3 kg/m 2 ; fasting glucose[FG]=94±14 mg/dL; total‐C=181±36 mg/dL; LDL‐C=115±31 mg/dL; HDL‐C=43±11 mg/dL; triglycerides [TG]=114±61 mg/dL). Participants with MS had smaller LDL particles (267±3Å vs. 271±3Å; p<0.0001) and 2.8 times more C in smaller LDL particles (p=0.001) than those without MS. The number of MS components was inversely correlated with LDL particle size (r=−0.322, p=0.006) and the percentage of HDL‐C in large HDL particles (r=−0.518, p<0.001), and positively correlated with the percentage of total‐C in small LDL particles (r=−0.298, p=0.011). Participants with TG>150mg/dL had smaller LDL particles (266±3Å vs. 271±2Å; p<0.001), less HDL‐C in large HDL particles (15±4% vs. 24±7%; p<0.001), and more HDL‐C in small HDL particles (29±6% vs. 20±7%; p<0.001) than those with normal TG. Participants with elevated waist circumference had 20% less HDL‐C in large HDL particles (20±5% vs. 24±8%; p=0.012). These data suggest that of the components of the MS, elevated TG may be a greater contributor to having a more atherogenic lipoprotein profile among Mexican Americans. Funded by Arizona State University.