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Meta‐analysis of interaction between dietary magnesium intake and genetic risk variants on diabetes phenotypes in the CHARGE Consortium
Author(s) -
Hruby Adela,
Ngwa Julius S.,
Meigs James B.,
Nettleton Jennifer A.,
McKeown Nicola M.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.243.1
Subject(s) - single nucleotide polymorphism , snp , diabetes mellitus , type 2 diabetes , medicine , endocrinology , genetic variation , population , cohort , biology , genetics , genotype , gene , environmental health
Little is known about whether genetic variation modifies the effect of magnesium (Mg) intake on two important diabetes risk factors: fasting glucose (FG) and insulin (FI). We examined interactions between dietary Mg and genetic variants associated with glucose (16 SNPs), insulin (2 SNPs), or Mg homeostasis and transport (8 SNPs), on FG or FI. Fifteen cohorts provided dietary, genetic, FG (mmol/L), and FI (pmol/L, ln‐transformed) data on up to 52,170 participants without diabetes. Analyses included: associations of Mg with FG or FI; associations of SNPs with FG or FI; and interactions between Mg and each SNP on FG or FI. Cohort‐level results adjusted for age, sex, energy intake, study center, and population substructure were meta‐analyzed using inverse variance‐weighted, fixed‐effect methods. Statistical significance was α=0.0015 (Bonferroni correction for 34 tests). FG (β: ‐0.012 mmol/L; 95%CI: −0.015, −0.008) and FI (−2.4% or β: −0.024 ln‐pmol/L; 95%CI −0.027, −0.020) were lower per 50 mg/day greater intake of Mg. No interaction was observed ( p =0.0198–0.9364). Consistent with other studies, higher Mg intake associated with lower FG and FI. There was no evidence that genetic variants at these loci influence the association between dietary Mg and FG or FI. Grant Funding Source : NIH/NIDDK Training Grant