Premium
NAD Metabolism: Mechanisms of lifespan extension in yeast and nicotinamide riboside utilization in a healthy 50 year old man
Author(s) -
Brenner Charles,
Trammell Samuel,
Mei Szu-Chieh,
Migaud Marie
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.231.2
Subject(s) - nad+ kinase , yeast , nicotinamide , riboside , biochemistry , nicotinamide phosphoribosyltransferase , nicotinamide adenine dinucleotide , biology , glycolysis , metabolism , enzyme , chemistry
More than 100 years after the discovery of the co‐enzyme requirement for glycolysis, more than 70 years after the discovery of niacins, more than 50 years after the discovery of the Preiss‐ Handler pathway of nicotinate utilization, and more than 10 years after the connections between NAD biosynthesis, calorie restriction and aging were discovered in yeast, we continue to find and attempt to fill major gaps in understanding of yeast and human NAD metabolism. In this paper, we will use LC‐MS and genetic analysis to dissect a surprising role for intercellular communication in yeast lifespan extension. We will also present a new chemical synthesis and a first‐in‐man clinical use of nicotinamide riboside, which reveals surprising differences in bioavailability from nicotinamide.