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Tackling Targets in Epigenetics
Author(s) -
Cole Philip A.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.230.3
Subject(s) - acetylation , epigenetics , drug discovery , computational biology , posttranslational modification , methylation , function (biology) , phosphorylation , biology , lysine , enzyme , protein function , chemistry , bioinformatics , microbiology and biotechnology , biochemistry , gene , amino acid
Enzyme‐catalyzed reversible post‐translational modifications on proteins, crucial in regulating normal and disease processes in biology, has become an emerging area for drug discovery. Our lab has developed a series of chemically‐based approaches to interrogate the structure and function of the enzymes that regulate protein phosphorylation, acetylation, octanoylation, and lysine methylation. We will describe recent results from these studies highlighting new insights and remaining challenges.