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Long non‐coding RNAs in epigenetic regulation
Author(s) -
Shiekhattar Ramin
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.227.3
Subject(s) - enhancer , epigenetics , biology , enhancer rnas , transcriptome , regulation of gene expression , computational biology , gene , non coding rna , long non coding rna , psychological repression , gene expression , transcriptional regulation , genetics , rna
Spatial and temporal regulation of gene expression is achieved through the instruction provided by the distal transcriptional regulatory elements known as enhancers. How enhancers transmit such information to their targets has been a subject of intense investigation. Recent advances in high throughput analysis of the mammalian transcriptome have revealed a surprising result indicating that a large number of enhancers are transcribed to non‐coding RNAs. While long non‐coding RNAs were initially shown to confer epigenetic transcriptional repression, recent studies have uncovered a role for a class of such transcripts in gene‐specific activation often from distal genomic regions. We will discuss our recent findings on the role of long non‐coding RNAs in transcriptional regulation with an emphasis on new developments on the functional links between long non‐coding RNAs and enhancers.