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Mitochondrial stress and metabolic dysfunction in skeletal muscle
Author(s) -
Muoio Deborah
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.221.2
Subject(s) - insulin resistance , endocrinology , carbohydrate metabolism , medicine , carnitine , metabolism , beta oxidation , skeletal muscle , mitochondrion , insulin , biology , chemistry , biochemistry
Application of targeted metabolic profiling tools has led to our finding that both diet‐induced and genetic forms of insulin resistance are accompanied by high rates of “incomplete” fat oxidation, perturbations in carnitine metabolism and acylcarnitine production, and impaired switching from fatty acid to carbohydrate substrate during the fasted to fed transition. These metabolic perturbations and the accompanying glucose intolerance are mitigated by genetic, nutritional or pharmacological maneuvers that alleviate mitochondrial carbon load. The role of mitochondrial stress as a potential cause of insulin resistance will be discussed.