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ER‐to‐cytosol membrane transport of pathogens
Author(s) -
Tsai Billy
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.219.1
Subject(s) - cytosol , microbiology and biotechnology , proteasome , ubiquitin , chemistry , biology , biochemistry , enzyme , gene
Misfolded ER proteins are transported to the cytosol and degraded by the ubiquitin‐dependent proteasome machinery. Strikingly, this ER‐to‐cytosol transport pathway is co‐opted by pathogens such as viruses and toxins during entry. How pathogens hijack this pathway to enter host cells is poorly understood, and is the focus of our research.