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Transcriptional and epigenetic regulation of lung development and regeneration
Author(s) -
Morrisey Edward
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.206.3
Subject(s) - epigenetics , biology , transcription factor , regeneration (biology) , microrna , cellular differentiation , signal transduction , cell fate determination , microbiology and biotechnology , genetics , gene
Development of the respiratory system is controlled by a myriad of transcription factors and signaling pathways that interact to regulate various aspects of cell differentiation. The result is a highly organized system of airways closely aligned with the pulmonary vasculature that is required for postnatal respiration. How these transcription factors and signaling pathways interact to promote cell lineage fate and differentiation is poorly understood but likely involves epigenetic mechanisms. Our lab has recently focused on epigenetic mechanisms that regulate cell differentiation in the developing and regenerating lung. Published and unpublished data from our lab support important roles for miRNAs and HDAC mediated mechanisms that drive cell type differentiation in a spatial and temporal specific fashion in the developing lung. Moreover, some of these pathways play critical roles in lung regeneration and may provide important new therapeutic targets for human lung disease.