MicroRNAs to Pathways in Stem Cells and Cancer | Zendy

Blelloch Robert | Zendy; Subramanyam Deepa | Zendy; Melton Collin | Zendy; Judson Robert | Zendy; Belair Cassandra | Zendy

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MicroRNAs to Pathways in Stem Cells and Cancer

Author(s) -

Blelloch Robert,

Subramanyam Deepa,

Melton Collin,

Judson Robert,

Belair Cassandra

Publication year - 2012

Publication title -

the faseb journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.709

H-Index - 277

eISSN - 1530-6860

pISSN - 0892-6638

DOI - 10.1096/fasebj.26.1_supplement.199.1

Subject(s) - microrna , embryonic stem cell , cancer stem cell , biology , cancer , stem cell , prostate cancer , cancer research , cellular differentiation , computational biology , microbiology and biotechnology , genetics , gene

Using a combination of global microRNA knockouts together with re‐introduction of individual microRNAs, we have been dissecting microRNA‐regulated pathways in embryonic stem cells and cancer. I will describe our latest findings in how microRNAs regulate the differentiation and de‐differentiation of stem cells. I will also describe recent results on the role of miRNAs in tumor progression using a mouse model of prostate cancer.

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