Premium
MicroRNAs to Pathways in Stem Cells and Cancer
Author(s) -
Blelloch Robert,
Subramanyam Deepa,
Melton Collin,
Judson Robert,
Belair Cassandra
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.199.1
Subject(s) - microrna , embryonic stem cell , cancer stem cell , biology , cancer , stem cell , prostate cancer , cancer research , cellular differentiation , computational biology , microbiology and biotechnology , genetics , gene
Using a combination of global microRNA knockouts together with re‐introduction of individual microRNAs, we have been dissecting microRNA‐regulated pathways in embryonic stem cells and cancer. I will describe our latest findings in how microRNAs regulate the differentiation and de‐differentiation of stem cells. I will also describe recent results on the role of miRNAs in tumor progression using a mouse model of prostate cancer.