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Effect of immuno modulator metallopeptide (IMMP) in acute toxic hepatitis induced with CCI4 in rats
Author(s) -
Rodríguez-Fragoso Lourdes,
Torres-Aguilar Lorena,
Reyes-Esparza Jorge
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.145.9
Subject(s) - toxic hepatitis , alkaline phosphatase , glycogen , glutathione , ccl4 , liver function , lipid peroxidation , liver function tests , hepatitis , carbon tetrachloride , medicine , liver injury , lymphocyte , endocrinology , immunology , pharmacology , chemistry , oxidative stress , enzyme , biochemistry , organic chemistry
Toxic hepatitis is a disease caused mainly by drugs or toxic agents. The IMMP is a drug with immunomodulatory properties and positive effects on the liver damage induced by autoimmune mechanisms and viral infections in patients and experimental models. For the study used 62 male Wistar rats (200 g), the animals were divided into twelve groups: 3control groups, 3 groups with IMMP, 3 groups with CCl4‐induced damage, and 3 groups treated with IMMP and damaged with CCl4. The IMMP was administered ip. at a dose of (100ng/Kg) and CCl4 was administered orally in single dose (4g/Kg). Animals were sacrificed at 24, 48 and 72 hours after CCl4 administration, we evaluated the levels of liver enzymes, glycogen, lymphocyte populations, glutathione, complete blood count (CBC) and liver weight. The IMMP restored alkaline phosphatase values in liver function tests, also stimulated the production of glutathione. The IMMP did not alter the levels of glycogen and lipid peroxidation in liver tissue damage. The IMMP showed a tendency to re‐establish normal values in CBC and liver weight. CD8+ and CD4+ lymphocytes increased with IMMP. In conclusion, the IMMP partially modified, acute toxic hepatitis.