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Pre‐pregnancy BMI Impacts Bone Loss across Pregnancy in Adolescents
Author(s) -
Young Bridget E,
McNanley Thomas,
Cooper Beth,
Witter Frank,
Harris Z. Leah,
O'Brien Kimberly
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.119.8
Subject(s) - pregnancy , medicine , gestation , vitamin d and neurology , obstetrics , endocrinology , gestational age , genetics , biology
Pregnant teens may be at increased risk for pregnancy‐induced bone loss. To assess the impact of dietary Ca and vitamin D status on bone loss, 171 teens (13–18 yrs) were followed from 22.3±5.9 weeks of gestation through delivery. Bone quality was assessed up to three times across pregnancy using calcaneus heel ultrasound (US) measures. Vitamin D, calcitropic hormones, and osteoprotegerin (OPG) were assessed at mid‐gestation and delivery. Speed of sound (SOS) at the heel decreased as pregnancy progressed (p<0.001, after controlling for multiple measures). SOS decreased by 8.6±17.0 m/s (over an 11.7±5.6 week interval), which is equivalent to a 0.28±0.54 decrease in T‐score. The change in SOS/week was positively associated with pre‐pregnancy weight (p=0.012) and BMI (p=0.007), such that heavier teens experienced less bone loss. Bone loss did not differ by race, age, gynecological age, or diet (caloric, protein, or Ca intake). The decrease in SOS across pregnancy was not influenced by mid‐gestation or delivery 25(OH)D, calcitriol, or PTH concentrations. Teens who did not lose bone SOS exhibited a trend for higher OPG at delivery (p=0.089). Maternal bone loss was not associated with infant weight, ponderal index, or gestational age at birth. These findings suggest that teens are at risk for pregnancy‐induced bone loss and BMI pre‐conception plays a role in adolescents’ skeletal response to pregnancy. USDA: 2005‐35200