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Significantly increased plasma levels of unbound‐VEGF in overweight/obese women
Author(s) -
Makey Kristina L,
Miele Lucio,
Chinchar Edmund,
Pei Ivy,
Robinson James,
Loftin Mark,
Waddell Dwight,
Huang Min,
Gu Jian-Wei
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1151.17
Subject(s) - overweight , obesity , medicine , endocrinology , angiogenesis , plasma levels , endostatin , vegf receptors , lean body mass , body weight
Angiogenesis promotes obesity. However, it is not clear whether overweight/obese women have a pro‐angiogenic phenotype in the circulation. Present study determines plasma levels of unbound‐ VEGF, endostatin, sFlt‐1 in 63 lean and overweight/obese adult women volunteers aged from 18–44. Average BMI of this group was 29.1±0.82 kg/m2, in which lean BMI was 21.95±0.47 kg/m2 (n=22) and overweight/obese BMI was 32.83±0.79 kg/m2 (n=41). ELISA assay (R&D Systems) showed that that plasma levels of unbound‐VEGF in overweight/obese young adult women were 52.26±9.6 pg/ml, significantly higher than plasma levels of unbound‐VEGF in lean young adult women, 27.34±4.99 pg/ml (P<0.01). Plasma levels of sFlt‐1 in lean (48.4±7.1 pg/ml) and overweight/obese women (52.1±9.5 pg/ml) were similar (P=0.557). There was no significant difference (P=0.442) in plasma levels of endostatin in lean (120±25 ng/ml) and overweight/obese women (109±27 ng/ml). The results support the hypothesis that overweight/obese women have a pro‐angiogenic phenotype in the circulation characterized by increased plasma levels of unbound‐VEGF. A potential therapeutic strategy for obesity will be targeting the VEGF pathway. (NIH/AA013821 and NIH/HL051971)