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Ventilatory pattern variability is associated with long‐term recovery following cardiac arrest and resuscitation in rats
Author(s) -
Xu Kui,
Kuang Youzhi,
Dick Thomas E,
Jacono Frank J
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1148.8
Subject(s) - resuscitation , medicine , cardiopulmonary resuscitation , ventilation (architecture) , cardiology , anesthesia , mechanical engineering , engineering
Predicting outcomes is essential for intervening to prevent mortality following cardiac arrest and resuscitation. We hypothesize that ventilatory pattern variability (VPV) reflects brainstem cardio‐respiratory regulation and propose to use VPV as a predictor for long‐term survival following cardiac arrest and resuscitation. Spontaneous ventilation was recorded (60 min) using whole‐body plethysmography in male Wistar rats before cardiac arrest (12 min) and 1d after resuscitation. VPV was analyzed including quantification of a nonlinear complexity index (NLCI) by comparing the sample entropy of original and surrogate data sets with similar autocorrelation functions. Overall survival (4d) was determined. VPV was similar before cardiac arrest but differed between survivor (n=5) and non‐survivor (died before 4d, n=2) groups after resuscitation. Non‐survivors had lower respiratory rate and higher coefficient of variation (CV) of respiratory cycle length compared to the survivors (RR: 80±13 vs. 104±11 bpm; CV: 0.27±0.09 vs. 0.15±0.02). NLCI was about 8‐fold higher in non‐survivor as compared to survivor rats (0.3±0.1 vs.0.04±0.02). Changes in VPV might distinguish surviving from non‐surviving rats early in the recovery phase after resuscitation, suggesting that VPV can be used as an outcome predictor following cardiac arrest and resuscitation. Supported by NS 38632, HL 087377, VA Research Service.