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Cardio‐Pulmonary Coupling I: Ejection Fraction Effects on Initiator Signals of Next Breathing
Author(s) -
Sun Xingguo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1148.12
Subject(s) - ventricle , cardiology , arterial blood , breathing , medicine , ejection fraction , pco2 , blood flow , stroke volume , anesthesia , heart failure
Since 2011 APS, we introduced new theory of breathing control. The lung breath generated O2, CO2 and [H+] oscillations as trigger of next breath. HYPOTHESIS We assessed the hypothesis that reduced left ventricle ejection fraction (EF) decrease the amplitude of arterial O2, CO2 and [H+] oscillations, due to the mixed‐chamber function of LV for these oscillation information. METHODS We recorded PO2, PCO2 and flow at mouth using 50Hz database; then based on dead space volume and functional residual capacity to calculate alveolar partial pressure oscillations of O2 and CO2 (same as blood). EF was used to calculate the magnitudes of arterial PO2 and PCO2 oscillation. RESULTS Calculated magnitudes of oscillation PO2 and PCO2 in alveolar were ~7mmHg. While 5:1 for ratio of heart rate to breathe, using EF=75% calculated magnitudes were ~5mmHg in arterial blood. But using EF=20%, the magnitudes decreased to <2mmHg in arterial blood. The lower EF, the weaker signal (magnitude) at artery. This will results that mean of O2 and CO2 at central chemical sensors is unstable, and then breath control ¡°gain¡± goes up and down. CONCLUSIONS Breathing lung generated O2 and CO2 oscillations magnitude decreased in arterial blood are influenced by EF is a mechanism of Cardio‐Pulmonary Intra‐Coupling