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Aerobic Interval Training Ameliorates Exertional Dyspnea by Improving the Ventilatory‐Hemodynamic Efficiency in Patients with Systolic Heart Failure
Author(s) -
HUANG SHU-CHUN,
Wang Jong-Shyan
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1146.3
Subject(s) - medicine , cardiology , ejection fraction , heart failure , interval training , hemodynamics , regimen , aerobic exercise , ventilatory threshold , vo2 max , workload , physical therapy , heart rate , blood pressure , computer science , operating system
This study investigated how aerobic interval training (AIT) affects dyspnea during daily activities by modulating ventilatory‐hemodynamic efficiency in patients with systolic heart failure (SHF, left ventricular ejection fraction<40%). Sixty patients with SHF were randomized to divided intoAIT (n=30) and general healthcare (GHC, n=30) groups. The AIT subjects performed the supervised hospital‐based training(3‐minute intervals at 40% and 80%VO 2peak ) for30 minutes/day, 3 days/week for 12 weeks; and the GHC subjects only engaged in general home‐based health care. Following the intervention, the AIT group exhibited higher VO 2peak , oxygen uptake efficiency slope (OUES), and lowerV E ‐VCO 2 slope than the GHC group. Additionally, AIT, but not GHC, increased cardiac output (CO)and reduced systemic vascular resistance (SVR)at the relative workload during the graded exercise test. This regimen simultaneously reduced total and exertional dyspnea‐related scores (MLHF‐ED) in Minnesota Living with Heart Failure Questionnaire. Moreover, reduced MLHF‐ED score were associated with increased OUES and CO and decreased V E ‐VCO 2 slope and SVR. Hence, we conclude that AIT ameliorates exertionaldyspnea by improving the ventilatory‐hemodynamic efficiency in patients with SHF.