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Acute aerobic exercise increases AdipoR1 and RAGE proteins and decreases HSP60 protein in skeletal muscle of physically inactive older adults
Author(s) -
Markofski Melissa M,
Timmerman Kyle L,
Reidy Paul T,
Dickinson Jared M,
Walker Dillon K,
Timmerman Jennifer Z,
Rasmussen Blake B,
Volpi Elena
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1142.5
Subject(s) - aerobic exercise , medicine , skeletal muscle , inflammation , endocrinology , glycation , receptor , basal (medicine) , insulin
Aerobic exercise training reduces inflammation and improves insulin sensitivity. Less known are the acute effects of aerobic exercise on skeletal muscle in older, physically inactive adults. We present preliminary data from a study designed to determine the effects of acute aerobic exercise on skeletal muscle markers of inflammation in non‐obese (n=9; BMI: 26.4±1.9 kg·m −2 ) inactive (3822±1502 steps/day; VO 2 peak: 22.7±3.5 mL·kg −1 ·min −1 ) older adults (72.9±3.9 yrs). After collection of a basal, resting muscle biopsy from the vastus lateralis, subjects walked on a treadmill for 45 min at 70% heart rate reserve, and muscle biopsies were collected 1 and 3 hrs post‐exercise. Protein expression was determined by Western blot. 1 hr post‐exercise, AdipoR1 and receptor for advanced glycation end product (RAGE) were 40.1% and 24.7% higher (p<0.05) than basal. When compared to basal, 3 hrs post‐exercise AdipoR1 was 42.6% higher, heat shock protein 60 (HSP60) was 41.4% lower, and there was a trend for elevation of toll‐like receptor 4 (32.3%). In conclusion, an acute bout of aerobic exercise in physically inactive older adults affects receptors and a ligand (e.g. HSP60) associated with inflammation. These acute effects on inflammation may be necessary for aerobic exercise to initiate muscle adaptation to increased activity in previously sedentary older adults. Future studies are warranted. NIH R01 AG030070 , P30 AG024832