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The effects of play‐based physical activity on metabolic signatures in adolescents
Author(s) -
Gulas Maria Eleni,
Collier Scott
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1142.29
Subject(s) - metabolome , metabolic equivalent , medicine , physical activity , physiology , endocrinology , chemistry , physical therapy , metabolite
Exercise has been shown to decrease risk factors and aid in weight management, however little is known regarding the mechanisms influencing these shifts by the metabolic shift. The purpose of this study was to compare the effects of 4 and 8 weeks (4w, 8w respectively) of play based activity versus a typical 8 week (C) summer break activity on key metabolic signatures. METHODS Twenty‐two adolescent children were divided into 8 and 4 week activity and control groups (8w, 4w, C) respectively. Subjects reported to the Vascular Biology and Autonomic Studies Laboratory on two separate visits, at the beginning and the end of 4 or 8 weeks of the exercise program to give urinary samples at which time a graded exercise test was given (GXT) and descriptive characteristics were recorded. A gas chromatography time‐of‐flight mass spectrum analysis was performed on the samples and the results analyzed by special software. RESULTS A valid PLS‐DA model was obtained between post‐exercise subjects in 8 week group and control group. Significant changes were shown in pantothenic acid (fold change, FC 4.19), adenosine (FC 1.66), glyceric acid (FC 2.91), and creatinine (FC 1.61). CONCLUSION These data indicate that 8 weeks of play‐based physical activity can positively affect the metabolome of adolescents which may prevent the future development of obesity and CVD. Research was partially supported by a grant from the BeActive North Carolina Partnership (Collier, PI)