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Can diabetes prevention program increase resting leg blood flow and antegrade shear rate in patients with metabolic syndrome?
Author(s) -
Johansson Rebecca E,
Limberg Jacqueline K,
McBride Patrick E,
Schrage William G
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1142.14
Subject(s) - medicine , cardiology , blood flow , blood pressure , femoral artery , brachial artery , diabetes mellitus , endocrinology , artery , waist , body mass index
No studies have tested whether healthy lifestyle changes can alter blood flow (BF) and shear patterns in adults with metabolic syndrome (MS). We hypothesized limb BF and conduit artery antegrade shear rate (ASR) would increase in the arm and leg of patients with MS after participation in a Diabetes Prevention Program (DPP). We also hypothesized DPP would reduce retrograde shear rate (RSR) and oscillatory shear index (OSI). Resting BF and shear rates (Doppler ultrasound of brachial and femoral arteries) were measured in MS patients (n=16, 51±2 yrs) before and after a 12‐week DPP. DPP reduced weight, waist circumference, blood pressure (BP) (p all<0.05), and glucose (p=0.06). Resting leg BF (38±22%, p=0.05) and ASR (12±6%, p=0.04) increased, and OSI tended to be lower (p=0.09). RSR did not change (p=0.30) in the leg. In contrast, DPP did not alter arm BF (p=0.29) or ASR (p=0.35), and RSR (32±15%, p=0.02) and OSI (52±30%, p=0.05) increased. We conclude resting leg BF and femoral artery ASR increases in response to a 12‐week DPP. These limb‐specific vascular adaptations may contribute to improvements in BP and blood glucose, and limit the progression of atherosclerosis in the leg circulation. Support: NIH R21 HL091397