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Hemodynamic and autonomic benefits of exercise training in myocardial infarction persists after 30 days of detraining
Author(s) -
Barboza Catarina,
Rocha Leandro Yanase,
Dias Danielle Silva,
Souza Romeu Rodrigues,
Caperuto Erico Chagas,
De Angelis Kátia,
Irigoyen Maria Cláudia,
Rodrigues Bruno
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1142.11
Subject(s) - bradycardia , medicine , baroreflex , heart rate , aerobic exercise , hemodynamics , cardiology , blood pressure , basal (medicine) , myocardial infarction , endocrinology , insulin
Male Wistar rats were divided in randomized groups: control (C), myocardial infarction (MI)+sedentary (SI), MI+exercise training (ET) (TI), MI+detraining (DI). After 12 weeks of ET, MI size although similar at the begining (~40±3%) was reduced at the end of the protocol in trained and detraining groups (TI: 19±6% and DI: 22±4%) when compared to SI (38±3%). TI group displayed increased maximum speed of running in comparison with C, SI, and DI; however, DI remained increased in relation to SI (C: 2.0±0.1; SI: 1.4±0.08; TI: 2.6±0.1 and DI: 1.9±0.1 Km/h). Basal lactate that was reduced by ET in TI, remained lower in DI as compared to SI animals. ET induced resting bradycardia and increase of mean arterial pressure in TI rats as compared to SI, and these adaptations remained after detraining in DI rats. Baroreflex sensitivity that was normalized by ET, persisted after detraining period, as evidenced by tachycardic (C: 3.2±0.1; SI: 1.9±0.4; TI: 3.0±0.1; DI: 2.9±0.4 bpm/mmHg) and bradycardic (C: 2.0±0.1; SI: 1.4±0.08; TI: 2.0±0.1; DI: 1.9±0.2 bpm/mmHg) responses. These findings indicate that ET is not only an effective tool in the management of MI derangements but also that these changes were kept working even after 30 days of detraining.