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Iron supplementation during lactation increases hemoglobin without an increase in iron status or oxidative stress
Author(s) -
Jorgensen Josh M,
Yang Zhenyu,
Lonnerdal Bo,
Chantry Caroline J,
Allen Lindsay H,
Dewey Kathryn G
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.114.8
Subject(s) - oxidative stress , lactation , ferritin , transferrin saturation , placebo , hemoglobin , isoprostane , medicine , hepcidin , endocrinology , chemistry , iron deficiency , zoology , anemia , pregnancy , biology , lipid peroxidation , genetics , alternative medicine , pathology
The RDA for iron (Fe) decreases to 9 mg/d during lactation, yet breastfeeding women are counseled to continue taking prenatal vitamin‐mineral supplements (PNV) postpartum. Our objective was to examine the effect of Fe‐containing PNV taken postpartum on biomarkers of Fe status and oxidative stress. Lactating women (n=114) were randomly assigned to consume daily one Fe‐free PNV plus either 27 mg of Fe (as Fe sulfate) or placebo for 3 mo. The placebo group took the tablets between meals, while those in the Fe group took the tablets either with (Fe‐with) or between meals (Fe‐between). Blood and urine samples were collected before and after the supplementation period to analyze hemoglobin (Hb), Fe status (ferritin, hepcidin, transferrin saturation (TfSat), and total plasma Fe) and oxidative stress (isoprostane and 8‐ hydroxy‐2‐deoxyguanosine (8‐OHdG)). The change from baseline in Hb was greater in the Fe‐with and Fe‐between groups compared to placebo (0.04, 0.25, and −0.37g/dL, respectively; P =0.027), yet only 1 woman in the placebo group had Hb < 12 g/dL at the end of the intervention period. There were no significant differences in ferritin ( P =0.09), hepcidin ( P =0.84), TfSat ( P =0.08), or total plasma Fe ( P =0.07). There were no group‐wise differences in isoprostane ( P =0.64) or 8‐OHdG ( P =0.67). Fe consumption during lactation increased Hb without a significant increase in Fe status and did not affect oxidative stress. Grant Funding Source : Center for Health and Nutrition Research at UC Davis