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Uterine artery vasoconstriction during exercise in rat pregnancy
Author(s) -
OˈHagan Kathleen P,
Lashley Christopher,
Supik David A,
Atkinson James T,
Murphy Robert J
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1138.7
Subject(s) - medicine , uterine artery , gestation , vasoconstriction , pregnancy , endocrinology , blood pressure , treadmill , cardiology , anesthesia , genetics , biology
Dynamic exercise initiates a decrease in uterine artery conductance (UtC) that is reduced at term pregnancy in rabbits [−40% (SD20) vs. −7% (SD15)]. We hypothesized that a gestational attenuation of the uterine vasoconstrictor response occurs in rats, a common model for pregnancy research. Nonpregnant (8NP) and pregnant (12P) rats were familiarized w/treadmill running and instrumented with a left carotid arterial catheter to measure blood pressure (BP) and a Transonic flowprobe for measurement of right UtBF. At day20 gestation (7–10d postsurgery), rats underwent exercise at 7 m/min (6%grade) for 5 min. Values are mean (SD). Pre‐exercise BP was lower [126 (13) vs. 111 (13) P=0.02], HR similar [456 (34) bpm] and UtBF [0.46 (0.25) vs 2.1 (1.6) ml/min, P<0.01] and UtC [0.35 (0.17) vs. 2.1 (1.7) ml‐min −1 /mmHg × 10 −2 P<0.01] elevated in the P rats. BP and HR increased with exercise in P and NP. Averaged over min 2–5 of exercise, the reduction in UtBF [−47% (12) vs. −25% (20), P=0.02)] and UtC [−49% (12) vs. −30% (20), P=0.02] was mildly attenuated in the P rats. Similar to rabbits, P rats demonstrate a reduced uterine vasoconstrictor response to dynamic exercise, although it appears less pronounced in the rat. Supported by MWU.