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Gamma‐tocopherol nebulization attenuates acute lung injury with burn and smoke inhalation in the ovine model
Author(s) -
Sousse Linda Elias,
Yamamoto Yusuke,
Enkhbaatar Perenlei,
Kraft Ed R,
Wright Charlotte L,
Taylor Alan,
Cox Robert A,
Hawkins Hal K,
Traber Lillian D,
Traber Maret G,
Szabo Csaba,
Herndon David N,
Traber Daniel L
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1137.12
Subject(s) - medicine , smoke inhalation , aerosolization , anesthesia , ards , smoke inhalation injury , inhalation , lung , airway
We hypothesize that nebulization of gamma‐tocopherol (g‐T) in the airway of our ovine model of acute respiratory distress syndrome (ARDS) will effectively improve pulmonary function following burn and smoke inhalation after 96 hrs. Adult ewes (n=14) were subjected to 40% total body surface burn and were insufflated with 48 breaths of smoke under deep anesthesia, in a double‐blind comparative study. A customized aerosolization device continuously delivered g‐T in ethanol from 3 to 48 hrs after injury (g‐T group, n=6), while the control group (n=5) was nebulized with only ethanol. All animals were sacrificed after 96 hrs. Lung g‐T concentration and PaO 2 /FiO 2 ratio significantly increased after g‐T nebulization compared to the control group (p<0.05). The following clinical parameters were significantly improved with g‐T treatment (p<0.05): pulmonary shunt, peak and pause pressures, lung bloodless wet‐to‐dry weight ratios, and obstruction. Delivery of g‐T into the lungs may be a safe, novel, and efficient approach for patients who have sustained oxidative damage to the airway. SUPPORT: GM66312‐01 and GM60668, and SHC 8630, 8520, 8954, 84060, 8450.