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The Role of Green Tea and Oxidative Stress in Heart Remodeling Induced by Tobacco Smoke Exposure
Author(s) -
Pereira Elenize Jamas,
Minicucci Marcos,
Polegato Bertha,
Portugal Priscila,
Batista Diego,
Modesto Pamela,
Fernandes Ana Angelica,
Rafacho Bruna,
Matsubara Luiz,
Zornoff Leonardo,
Paiva Sergio,
Roscani Meliza,
Azevedo Paula
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1133.8
Subject(s) - ventricle , oxidative stress , tobacco smoke , superoxide dismutase , hydroxyproline , medicine , catalase , glutathione peroxidase , diastole , cardiology , endocrinology , zoology , blood pressure , biology , environmental health
The objective of this study is to evaluate the role of green tea (GT) in heart remodeling induced by exposure to tobacco smoke (ETS). Methods Wistar rats were allocated in 3 groups: C (control – standard diet); S (smoke – standard diet); SGT (smoke + diet with GT 0,25%). After 2 months, animals were submitted to echocardiography, isolated heart study, and oxidative stress evaluation. One way anova test was performed. Results ETS leaded to an increase in left atrium area (C 0, 21±0, 03 ; S 0, 24±0,032; SGT 0, 2±0, 031) (p=0,02). End diastolic ventricle diameter/weight (p=0,5) and ventricle mass index (p=0,8) were similar. ETS impaired Systolic function: shortness fraction (C 59,5± 2,8; S 53,9±5, 9; SGT 54,5±4, 1) (p=0,03). No fibroses was evidenced: Hydroxyproline (C 2, 7±0, 6; S 3,0 ±0, 2 ; SGT 2, 9±0, 5 ) ( p=0, 5 ) ETS increased oxidative stress, that was attenuated by GT: hydroperoxides (C 133,4±14,6; S 175,9±11,5; SGT 132,0±15,4) (p<0,001); catalase [C 80,5(78,3–86,1); S 65,6(46,7–76,8); SGT 112,4(82,5–129,4)]; superoxide dismutase (C 19,5±1,9; S 11,2±0,8; SGT 19,9±2,2)(p<0,001); glutathione peroxidase (C 37,4±4,8 S 17,5±3,9 SGT37,8±3,7) (p<0,001). Conclusion It is possible that GT attenuates cardiac remodeling induced by ETS in part due to reduction of oxidative stress.