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The role of Green Tea in experimental myocardial infarction
Author(s) -
Lustosa Beatriz,
Batista Diego,
Polegato Bertha,
Minicucci Marcos,
Pereira Elenize,
Okoshi Katashi,
Matsubara Luiz,
Zornoff Leonardo,
Paiva Sergio,
Gonçalves andrea,
azevedo Paula
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1133.6
Subject(s) - ventricle , myocardial infarction , medicine , cardiology , diastole , diastolic function , cardiac function curve , preload , infarction , blood pressure , hemodynamics , heart failure
The objective of this study is to evaluate whether green tea attenuates cardiac remodeling after acute myocardial infarction. Methods Wistar rats were allocated in 4 groups: C (control); GT (diet with green tea 0,25%); MI (infarcted group) IGT (infarcted group with green tea 0,25%). After 3 months, animals were submitted to echocardiography and isolated heart study. Two way anova and Holm Sidak tests were performed. Results Both infarcted groups showed the same infarction size(p=0,7). Echocardiographic data without interaction:Left atrium/weight (with MI 14,4±0,5; without MI 10,7±0,6)(p<0,001)(with GT 13,0±0,5; without GT 12,1±0,6)(p=0,2); end diastolic ventricle diameter/weight (with MI 21,2±0,6; without MI 17,4±0,7)(p<0,001)(with GT 19,1±0,6; without GT 19,7±0,7)(p=0,5). Systolic function: Fractional area change (with MI 41,2±1,8; without MI 70,8±2) (p<0,001)(with GT 56,1±1,8; without GT 55,8±2)(p=0,9). Data with interaction (p=0,04) E wave deceleration time (EDT)(C 48,5±2,9; GT 45±2,6; MI 35,3±2,5; MIGT 43±2,4). Isolated heart study: Maximum systolic pressure (with MI 143±12; without MI 104±24)(p<0,001)(with GT 133±28; without GT 114±24)(p=0,03). Conclusion green tea improved systolic and diastolic function in isolated heart study, increasing EDT. Supported by FAPESP.