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Pentoxifylline reduces myocardial oxidative stress induced by exposure to tobacco smoke
Author(s) -
Azevedo Paula Schmidt,
Polegato Bertha,
Portugal Priscila,
Batista Diego,
Lustosa Beatriz,
Rafacho Bruna,
Oliveira Fernando,
Mascoli Alexander,
Roscani Meliza,
Fernandes Ana Angélica,
Zornoff Leonardo,
Paiva Sergio,
Matsubara Luiz,
Pereira Elenize,
Minicucci Marcos
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1133.3
Subject(s) - pentoxifylline , oxidative stress , ventricle , medicine , superoxide dismutase , glutathione , tobacco smoke , endocrinology , cigarette smoke , chemistry , cardiology , biochemistry , enzyme , environmental health
The objective of this study is to evaluate the role of pentoxifylline (P) in heart remodeling induced by exposure to tobacco smoke (ETS). Methods Wistar rats were allocated in 4 groups: C (control); S (smoke); P (diet with P 100mg/kg) SP (smoke + diet with P100mg/kg). After 2 months, animals were submitted to echocardiography, isolated heart study, and oxidative stress evaluation. Two way anova and Holm Sidak tests were performed. Results ETS leaded to an increase in left atrium area (p=0,04) and in left ventricle weight (p=0,04) and to impairment of ventricle function that was improved by pentoxifylline as observed in maximum positive derivative (C=3851±245; P=3500±400; S=2725±310; SP=3950± 310) (p=0,01). ETS increased oxidative stress that was attenuated by pentoxifylline: lipoperoxides (C=133,4±14,7; S=175,8±11,5; P=100,0±14,5; SP=128,3±11,9) (p<0,001), Glutathione peroxidases (C=37,4±4,8; S=17,519±3,9; P=33,6±6,4; SP=37,2±5,3) (p<0,001), superoxide dismutase (C=19,4±1,9; S=11,2±0,89; P=16,4±1,6; SP=21,7±2,9) (p<0,001). Conclusion It is possible that pentoxifylline attenuates cardiac remodeling induced by ETS, in part due to reduction of oxidative stress.