Premium
Investigation of Hypersensitivity to PEGylated Particles For Use in Drug Delivery
Author(s) -
Simmons Ken,
Nejati Elham,
Johnson Rebecca,
Pearce Robert,
Albrecht Ralph,
Mecozzi Sandro
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1120.2
Subject(s) - drug delivery , polyethylene glycol , drug , peg ratio , medicine , ovalbumin , pharmacology , nanotechnology , chemistry , materials science , immunology , antigen , organic chemistry , business , finance
Nanoparticles have shown promise in the field of drug delivery. Many have the potential to improve the solubility and safety‐profile of our current drugs. Polyethylene glycol is commonly used as the hydrophilic segment in many polymer‐based nanoparticle systems. There have been reports of hypersensitivities to PEGylated particles. In order for these novel drug delivery systems to reach clinical use, it is essential to investigate the mechanism behind their allergic‐like responses. This study examines hypersensitivities to PEGylated particles in a canine model. Dogs are a very sensitive model for this type of allergy, which is thought to be caused through either direct complement activation or an antibody‐based mechanism. We have tested a number of PEG‐fluorocarbon polymers using this model and have performed blood analysis pre and post injection. Current results indicate an antibody‐mediated pathway is likely responsible for this type of hypersensitivity. This project was supported by the UW Institute for Clinical and Translational Research funded through a National Institutes of Health Clinical and Translational Science Award, 1UL1 RR025011, and the STEP program administered by the Wisconsin Alumni Research Foundation.