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Wogonin reduces infarct size and improves ventricular function in chronic myocardial ischemia rats
Author(s) -
Lin Su-Man,
Tsai Shen-Kou,
Chih Chun-Lien,
Nien Mao-Wei,
Huang Shiang-Suo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1114.12
Subject(s) - wogonin , medicine , scutellaria baicalensis , cardiology , myocardial infarction , ischemia , ligation , ventricle , ventricular remodeling , reperfusion injury , traditional chinese medicine , pathology , alternative medicine
Wogonin (5,7‐dihydroxy‐8‐methoxyflavone), a main active ingredient of Scutellaria baicalensis Georgi (S baicalensis), has been shown to possess antioxidant and anti‐inflammatory effects and to attenuate myocardial ischemia and ischemia‐reperfusion injury. The present study was designed to investigate the action and mechanism of wogonin on ventricular remodeling after chronic myocardial infarction (MI) in rats, which was induced by the permanent ligation of the left anterior descending artery. Rats were randomly allocated to three groups and treated with vehicles or wogonin (0.1 and 0.01 μg/kg, intraperitoneal) once daily for thirty days. We used echocardiography to real time evaluate myocardial function. In addition, We examined the effects of wogonin by hemodynamic studies, histologic examinations, and real‐time quantitative polymerase chain reaction. Rats treated with wogonin (0.1 μg/kg) had significantly increased fractional shortening of the left ventricle, ameliorated left ventricular dilatation, reduced left ventricular end‐diastolic pressure, and reduced mortality and infarct size. Wogonin also attenuated the collagen deposition and the expression of myocardial atrial natriuretic peptide and transforming growth factor‐β1 mRNAs. Overall, our results suggest that wogonin can potentially protect heart from detrimental remodeling.