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Fructose‐rich Diet From Weaning To Adulthood: Effects On Sympathetic Activity In Rats
Author(s) -
Andrade Romario Pacheco,
Araujo Iara Cristina,
Lopes Ingrid Jarzinski,
Lopes Bruna Kogici,
Santos Fernando,
Irigoyen Maria Claudia,
Fiorino Patricia,
Farah Vera
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1104.10
Subject(s) - heart rate , medicine , endocrinology , atropine , fructose , blood pressure , atenolol , autonomic nervous system , hypertriglyceridemia , weaning , sympathetic nervous system , chemistry , cholesterol , triglyceride , biochemistry
Administration of a diet rich in fructose initiates a series of metabolic events resulting in hypertriglyceridemia, hypertension and glucose intolerance. The purpose of this study was to evaluate the cardiovascular and autonomic modulation induced by fructose intake during 8 weeks. Weaned (21 days old) male Wistar rats (50–60g) were divided in 2 groups and they were followed for 8 weeks: Control (CG) and Fructose (FG, 10% in drinking water). Arterial pressure (AP) and heart rate (HR) were directly recorded using a data acquisition system (Windaq, 2 KHz) in conscious and awake rats. Cardiac autonomic modulation was evaluated using spectral analysis of HR variability and after pharmacological blockade (Atenolol, 8mg/Kg and Atropine, 4mg/Kg). FG showed an increase of mean AP (120±3.1 mmHg) when compared to CG (98±1.6 mmHg). No changes in heart rate were observed, although autonomic balance increased in FG (0.12±0.02) compared to CG (0.04±0.01). Sympathetic tonus was increased in FG (86±7.2 bpm) when compared with CG (49±3.6 bpm) with no differences in vagal tonus. However, intrinsic HR was significantly lower in FG (375±7.2 bpm) when compared with CG (405±8.2 bpm). In conclusion, these data suggest that metabolic changes induced by frutose‐rich diet during life spam in rats are accompanied by hypertension associated with sympathetic overactivity. Supported by: FAPESP(2009/52556‐7) and PIBIC/Mackpesquisa