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Alterations of Zinc, Copper, and Magnesium Concentrations During and After Open Heart Surgery
Author(s) -
YAN Ying-Qun,
LIU Xiao-Cheng,
JING Wen-Bin,
BAI Xiao-Yan,
YANG Qin,
HE Guo-Wei
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1103.26
Subject(s) - cardiopulmonary bypass , magnesium , zinc , chemistry , copper , cobalt , medicine , surgery , anesthesia , inorganic chemistry , organic chemistry
Trace elements such as copper (Cu), cobalt, and arsenic may contribute to myocardial dysfunction and Zinc (Zn) deficiency may increase the susceptibility of the phospholipid cell membrane to free‐radical damage and oxidative changes. Magnesium (Mg) is an important determinant of the resting membrane potential of cardiac cell membranes. We studied the concentration of these elements in cardiac surgery. Fifty‐four consecutive patients for elective coronary artery bypass grafting (CABG) (30) and valve replacements (VR) (24) were studied. Blood samples were collected every 30 min (T1–T5) during cardiopulmonary bypass (CPB) and postoperatively (T6–T9). Plasma Cu, Zn, and Mg were measured with flame atomic absorption spectrophotometry. The concentrations of Zn, Cu, and Mg were significantly different during and after CPB (p<0.01). The Zn concentration at T7 and T8 (p<0.01) and the Cu concentration at T1, T9 (p<0.05) were significantly different between two groups. However, the Mg concentration had no significant difference between two groups (p>0.05). In patients undergoing VR or CABG, the concentrations of Zn and Cu decreased considerably during CPB and recovered after CPB with more rapid recovery of Zn in CABG than VR patients whereas Cu concentration recovered more rapidly in VR patients. These may have significant clinical implications. Supported by International S&T Cooperation Program of China 2009DFB30560; National Basic Research Program of China 2010CB529502; Tianjin Municipal S&T Com 09ZCZDSF04200 & 10JCYBJC26400; NSFC 81170148; GRF CUHK4789/09M; CUHK2041688.