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Effects of low maternal aldosterone on offspring cardiovascular development
Author(s) -
McKee Travis,
Knoblich Penny
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1102.6
Subject(s) - aldosterone , offspring , medicine , blood pressure , zona glomerulosa , endocrinology , adrenalectomy , fetus , pregnancy , diastole , cardiology , angiotensin ii , biology , genetics
Maternal conditions are well known to affect fetal cardiovascular development. This study was designed to investigate in spontaneously hypertensive rats (SHR), the effects of maternal aldosterone suppression on the development of hypertension in the offspring. Right adrenalectomy was combined with cryodestruction of the zona glomerulosa of the left adrenal gland of SHR females. A sham procedure was performed on control rats. Rats were mated and offspring were studied at 10–13 weeks of age. Male rats were implanted with a PA‐C40 remote monitoring device placed into the femoral artery to record cardiovascular parameters for 4 weeks. Systolic (mmHg), diastolic (mmHg), and mean blood pressure (mmHg), heart rate (beats per minute), and activity levels were recorded. Data was sorted by activity level, and parameters were compared to evaluate same age data points between freeze and sham groups. No differences were found in any of the parameters between the offspring from sham and adrenal frozen maternal rats. These results suggest that lowered maternal plasma aldosterone levels do not adversely affect fetal cardiovascular development. This project was supported by funding from the Department of Biological Sciences, Minnesota State University, Mankato.