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Oxidative stress and hemodynamics alterations induced by fluoxetine
Author(s) -
Lagranha Claudia Jacques,
Silva Aline Isabel,
Galindo-Novaes Ligia,
Manhaes-de-Castro Raul,
Costa-Silva Joao Henrique,
Souza Sandra Lopes
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1102.2
Subject(s) - fluoxetine , hemodynamics , oxidative stress , heart rate , endocrinology , medicine , blood pressure , superoxide dismutase , catalase , antidepressant , pharmacology , serotonin , hippocampus , receptor
The association between antidepressant and risk of cardiovascular disease remains controversial. Antidepressants such as selective serotonin reuptake inhibitors (i.e fluoxetine also known as Prozac) are now prescribed not only for depression, although the possible effect related to the drug transfer from mother to child during breast‐feeding in developmental ages it is not well known. With this our aim was evaluate the effect of fluoxetine treatment during the lactation time in the levels of oxidative stress in heart and brainstem, and hemodynamics parameters. The treatment was carryout during the lactation time using 10mg/Kg B.W. (i.p injection) in female Wistar rats. In vivo was evaluated body weight, blood pressure, heart rate, intrinsic heart rate, parasympathetic and sympathetic tonus and in vitro we evaluate the levels of oxidative stress (Malondialdeyde‐MDA), antioxidant enzyme (superoxide dismutase‐SOD and catalase activity‐CAT) in heart and brainstem. Our results suggest that chronic treatment with fluoxetine during the critical period of development induce significant increase in oxidative stress and modulation in hemodynamics parameters, which could be associated with cardiovascular disease in adulthood. The present study receives financial support from FACEPE and CNPq.