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Analysis of renal hemodynamics and pressure‐natriuresis in Dahl salt‐sensitive rats
Author(s) -
Beard Daniel A
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1098.3
Subject(s) - natriuresis , medicine , endocrinology , renal blood flow , renal function , diuresis , blood pressure , nephron , prehypertension , chemistry , kidney
Analysis of data on blood flow regulation, filtration, and urine output in Dahl S rats fed on high‐salt (hypertensive) and low‐salt (prehypertensive) diets using simple mathematical models of renal blood flow regulation, glomerular filtration, and solute transport in a nephron reveals the minimal differences between the hypertensive and prehypertensive cases necessary to explain the observed data. It is determined that an increase in renal afferent arterial resistance is able to explain the qualitative differences in observed flows, filtration rates, and glomerular pressure as well as the shift in the pressure‐natriuresis and pressure‐diuresis relationships in animals fed on high compared to low salt diets. Model analysis predicts a decrease in the effective sodium pumping rate in the ascending limb of the loop of Henle in high‐salt fed animals compared to low‐salt fed controls. The finding that a change in afferent arterial tone can explain differences in renal physiological function in high‐salt versus low‐salt fed Dahl S rats suggests the novel hypothesis that, if a shift in the pressure‐natriuresis relationship is the primary cause of elevated arterial pressure in high‐salt fed Dahl S rats, then the primary cause of chronic hypertension in the Dahl S rat is an increase in renal afferent arterial resistance.