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A new biotelemetry system to monitor blood flow velocity, blood pressure and temperature in small animals: Preliminary data from cigarette smoke exposed SH rats
Author(s) -
Maggie Lin,
Griffiths Leigh G.,
Uyeminami Dale,
Johnson Katherine,
Pinkerton Kent E.,
Pitsillides Koullis
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1098.16
Subject(s) - biotelemetry , telemetry , blood pressure , blood flow , abdominal aorta , biomedical engineering , medicine , aortic pressure , aorta , anesthesia , cardiology , engineering , aerospace engineering
Telemetry monitoring of blood pressure and temperature in unrestrained rats is a relatively established procedure. However, monitoring blood pressure alone does not provide a comprehensive assessment of the physiologic changes occurring when animals are exposed to cigarette smoke. We have used a newly developed biotelemetry system capable of measuring, blood flow velocity, blood pressure and temperature in unrestrained SH rats. The biotelemetry device (EG2‐V1S2TM2, Endosomatic Systems Inc, Davis, CA) was implanted in 340–380 g SH rats under inhalational general anesthesia. A 1.5mm diameter Doppler flowprobe was attached around the abdominal aorta just caudal to the renal artery and a 1F (330μm diameter) solid state pressure sensor was inserted in the abdominal aorta at the level of the aortic trifurcation. Preliminary data from this new system show that after 30 min of 60 mg/m 3 cigarette smoke exposure, average systolic flow velocity increased by 33.5% and average systolic blood pressure increased by 47% of pre‐exposure levels. The described biotelemetry system combines data from a Doppler flowprobe and a 1F high fidelity pressure sensor for making direct measurements of both blood flow velocity, blood pressure and temperature. This totally implantable telemetry system is suitable for small animals, such as rats, and provides new information regarding the effects of cigarette smoke on vascular resistance.