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ageLOC Vitality enhances sexual functions in normal and impotent models
Author(s) -
Wu Zimei,
Dong Yunzi,
Zhao Chunsheng,
Zhang Yan,
Tan Ningzhi,
Lu Jihong,
Zhu Jia-Shi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1095.1
Subject(s) - vitality , medicine , endocrinology , chemistry , biology , genetics
Based on the differentiated gene expression in skeletal muscle and brain tissue between the young (5 mo) and old (25 mo) mice, ageLOC Vitality was formulated with ingredients ( Cordyceps sinensis Cs‐4 and extracts from ginseng and pomegranate) that oppose the age associated changes. Previously we reported that it improved maximal/endurance exercise, glucose metabolism, anti‐oxidation and mitochondria functions in old mice (FASEB J. 2011 25:1114.9; 1049.2). In this study we examined its effect on sexual functions in rats and mice. (1) Rats (3 mo) underwent orchiectomy (OE), resulting in prolongation of erection latency (EL) (p<0.01). After >5 wks of rest, OE rats received 3 days of vehicle or Vitality at 0.2 or 0.8 g/kg by gavage . Vitality shortened EL in OE rats that received a single dosing at both dosages of Vitality and after 3 days at 0.8 g/kg, compared to OE controls (p<0.01). (2) ICR mice (8 mo) received Vitality at 0.4 or 0.8 g/kg for 20 days and were examined for capture latency (CL) and capture times within 20 min (CT 20 ). There were no significant changes in plasma Dihydrotestosterone or Follicle‐Stimulating Hormone on Day 20, compared to controls. CL was shortened with Vitality 0.4 g/kg (p=0.03). CT 20 was increased by 78% on Day 3 at 0.4 g/kg (p<0.01), and 109% on Day 20 at 0.8 g/kg (p<0.01). In conclusion: ageLOC Vitality enhances sexual behavior by shortening EL in OE rats, and by shortening CL and increasing CT 20 in mice.