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Metabolic and cardiovascular effects of AT1 receptor blockade in rats with diet‐induced obesity
Author(s) -
Junior Silvio Assis Oliveira,
Guizoni Daniele Mendes,
Martinez Paula Felippe,
Torres Bárbara Pereira,
Campana Alvaro Oscar,
Padovani Carlos Roberto,
Okoshi Katashi,
Okoshi Marina Politi,
Cicogna Antonio Carlos
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1093.9
Subject(s) - losartan , medicine , endocrinology , angiotensin ii receptor type 1 , blockade , obesity , glycemic , angiotensin ii , receptor , diabetes mellitus
Causes of metabolic and cardiovascular disturbances in obesity are poorly understood. This study analyzed whether the angiotensin II receptor blockade reverses abnormalities in diet‐induced obesity. Wistar‐Kyoto rats (n=40) were subjected to control (C) or hypercaloric diet (OB) for 30 weeks and then assigned to four groups: C, C+Los, OB, and OB+Los. Los‐groups received losartan (30mg/kg/day) during five weeks. Subsequently, cardiac structures and function were assessed by echocardiography. Glycemia was studied by tolerance glycemic curve. OB‐groups presented higher body mass and adiposity. Other results are in the table. Conclusion Losartan improves metabolic and cardiovascular profile in diet‐induced obesity.